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Observe Carefully (one)crofelemer raises levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Crofelemer has the potential to inhibit CYP3A4 at concentrations anticipated while in the gut; unlikely to inhibit systemically because minimally absorbed.Hyponatremia: Clinically substantial hyponatremia (sodiu